Aging And Young Blood - 944 Words

Aging is an important factor that impairs humans’ brains structurally and functionally thus leads to cognitive disorders which negatively affect elder people’s normal life. Previous studies have shown that exposing aged animals to young blood can enhance stem cell function in various organs such as liver and brain. Inspired by these studies, Villeda and co-researchers want to find out if exposure to young blood can counteract age-related impairments and enhance aged brains. In Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice, Villeda and co-researchers work with mice to study the effects of exposure to young blood on the aged mice’s brains. Villeda’s research focuses on the hippocampus, a†¦show more content†¦They then use Golgi analysis to assay for the structural changes that regulate synaptic plasticity in hippocampi of the two groups of parabionts. The result shows that exposure to young blood increases the number of dendritic spine in the aged DG of heterochronic parabionts compared to isochronic parabionts but does not affect dendritic complexity. Next, they address functional changes in the hippocampi with extracellular electrophysiological recordings of field population spikes on hippocampus slices. The calculated long-term potentiation (LTP) values of heterochronic parabionts, which reflect learning and memory abilities, remain above baseline level, while isochronic parabionts’ LTP values reach baseline level later. Synaptic strength shows no difference between the two groups. Villeda and co-researchers suggest that exposure to young blood improves synaptic plasticity level in aged hippocampi. To prove the decline of learning and memory abilities of aged mice and verify the enhancement at functional level caused by exposure to young blood, Villeda and co-researchers set up two cognitive testings, contextual fear conditioning and radial arm water maze (RAWM). T he unpaired aged mice are divided into two groups, with one group injected with young plasma and the other injected with agedShow MoreRelatedEssay On Aging1000 Words   |  4 PagesYoung blood reverses cognitive function and synaptic plasticity in aging Aging causes structural and functional changes in brain. As aging population has become a burden, it is essential to study aging brain aiming to maintain cognitive integrity. Previous studies indicated that young blood improves the function of stem cells in organs including brain by heterochronic parabiosis model. However, data is lacking whether regeneration or beyond occurs by this model. The authors Villeda et al., hypothesizedRead MoreThe Fountain Of Health : A Disease Caused By Degeneration Of Your Brain962 Words   |  4 Pagesinjecting a young humans blood, which is someone who is very young and healthy, into someone who is old who is having issues and although some may argue that this isn’t ethical nor correct I believe that swapping young blood for old, to reverse aging should be allowed. First of all once people enter the aging process they also enter a point in their lives where they will be prone to many diseases, which includes diseases such as alzheimer s and heart-enlargement. In the article â€Å"Swapping Young blood forRead MoreAging Population A Growing Challenge1018 Words   |  5 Pages Radka. Aging population a growing challenge. Slovak Spectator 08 Sept. 2014: 12. Newspaper Source. Web. 18 Nov. 2015. 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